University of Colorado Denver - Anschutz Medical Campus
Fabrice’s early studies focused on the control of smooth muscle and endothelial cell function by ion channels, providing some of the first measurements of membrane potential, calcium signaling, and diameter imaging in mouse brain microcirculation. Developing these approaches in mouse was a tour de force that lets his lab to use genetic models and investigate potential treatments for cerebral diseases with a vascular component. The emerging view from his work on CADASIL, an archetypal monogenic form of small vessel disease of the brain, is that fundamental alterations in extracellular matrix proteins disrupt the ion channel repertoire controlling vascular reactivity, and then cerebral hemodynamics, at a very early stage. Currently, the Dabertrand Lab is aimed at understanding the disruption of neurovascular coupling in disorders involving extracellular matrix protein alterations to shed light on vascular dementia.
Daniel M. Collier, Ph.D.
University of Tennessee Health Science Center
The Collier Lab studies ion channel function in cardiovascular physiology and disease. With techniques that range from single channel electrophysiology to fast 4D imaging using a diSPIM system, we are able to connect ion channel activity and pharmacology to vascular function in ex vivo pressurized resistance arteries. While Dr. Collier typically catches fewer fish than Dr. Gonzales, they are generally better quality.
Swapnil K. Sonkusare, Ph.D.
Molecular Physiology and Biological Physics
Robert M. Berne Cardiovascular Research Center
University of Virginia - School of Medicine
Dr. Swapnil Sonkusare's laboratory studies how calcium signaling networks within cellular microdomains regulate vascular function, and are impaired in disease conditions. The ultimate goal is to discover much needed new therapeutic targets for treating vascular dysfunction in cardiovascular diseases.
Thomas A. Longden, Ph.D.
Department of Physiology
University of Maryland, School of Medicine
The Longden lab is focused on understanding the biological mechanisms that regulate how blood flows throughout the brain in health and in disease, with a particular focus on the roles of vascular ion channel and GPCR signaling networks. The lab is located in the department of physiology at the University of Maryland Baltimore School of Medicine.