PUBLICATIONS

Ex vivo ocular perfusion model to study vascular physiology in the mouse eye

Ahmed M Eltanahy, Cristian Franco, Priscilla Jeyaraj, Shipra Goswami, Elena Hughes, Albert L Gonzales

Exp Eye Res. 2023 Aug;233:109543. doi: 10.1016/j.exer.2023.109543. Epub 2023 Jun 28.

Intraluminal pressure elevates intracellular calcium and contracts CNS pericytes:
Role of voltage-dependent calcium channels

Nicholas R Klug, Maria Sancho, Albert L Gonzales, Thomas J Heppner, Rochelle Irene C O'Brien,
David Hill-Eubanks, Mark T Nelson

Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2216421120. doi: 10.1073/pnas.2216421120

Nitric oxide signals through IRAG to inhibit TRPM4 channels and dilate cerebral arteries

Sher Ali, Alfredo Sanchez Solano, Albert L Gonzales, Pratish Thakore, Vivek Krishnan, Evan Yamasaki, Scott Earley

Function, 09 October 2021 https://doi.org/10.1093/function/zqab051

Pericytes: Intrinsic Transportation Engineers of the CNS Microcirculation

Ahmed M. Eltanahy, Yara A. Koluib, Albert Gonzales

Review Article: Front. Physiol., 23 August 2021 | https://doi.org/10.3389/fphys.2021.719701

PIP2 Improves Cerebral Blood Flow in a Mouse Model of Alzheimer’s Disease

Amreen Mughal, Osama F Harraz, Albert L Gonzales, David Hill-Eubanks, Mark T Nelson

Function (Oxf). 2021 Feb 22;2(2):zqab010. doi: 10.1093/function/zqab010.

Contractile pericytes determine the direction of blood flow at capillary junctions

Albert L. Gonzales, Nicholas R. Klug, Arash Moshkforoush, Jane C. Lee, Frank K. Lee, Bo Shui, Nikolaos M. Tsoukias, Michael I. Kotlikoff, David Hill-Eubanks, Mark T. Nelson

Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):27022-27033. doi: 10.1073/pnas.1922755117.

Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility.

Pritchard HAT, Gonzales AL, Pires PW, Drumm BT, Ko EA, Sanders KM, Hennig GW, Earley S.

Sci Signal. 2017 Sep 19;10(497). pii: eaan2694. doi: 10.1126/scisignal.aan2694.

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow.

Longden TA, Dabertrand F, Koide M, Gonzales AL, Tykocki NR, Brayden JE, Hill-Eubanks D, Nelson MT

Nat Neurosci. 2017 May;20(5):717-726. doi: 10.1038/nn.4533. Epub 2017 Mar 20.

Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation.

Sullivan MN, Gonzales AL, Pires PW, Bruhl A, Leo MD, Li W, Oulidi A, Boop FA, Feng Y, Jaggar JH, Welsh DG, Earley S.

Sci Signal. 2015 Jan 6;8(358):ra2. doi: 10.1126/scisignal.2005659.

Vascular TRP channels: performing under pressure and going with the flow.

Hill-Eubanks DC, Gonzales AL, Sonkusare SK, Nelson MT.

Physiology (Bethesda). 2014 Sep;29(5):343-60. doi: 10.1152/physiol.00009.2014.

A PLCγ1-dependent, force-sensitive signaling network in the myogenic constriction of cerebral arteries.

Gonzales AL, Yang Y, Sullivan MN, Sanders L, Dabertrand F, Hill-Eubanks DC, Nelson MT, Earley S.

Sci Signal. 2014 May 27;7(327):ra49. doi: 10.1126/scisignal.2004732.

Dopaminergic neurotoxicants cause biphasic inhibition of purinergic calcium signaling in astrocytes.

Streifel KM, Gonzales AL, De Miranda B, Mouneimne R, Earley S, Tjalkens R.

PLoS One. 2014 Nov 3;9(11):e110996. doi: 10.1371/journal.pone.0110996. eCollection 2014.

Ca(V)3.2 channels and the induction of negative feedback in cerebral arteries.

Harraz OF, Abd El-Rahman RR, Bigdely-Shamloo K, Wilson SM, Brett SE, Romero M, Gonzales AL, Earley S, Vigmond EJ, Nygren A, Menon BK, Mufti RE, Watson T, Starreveld Y, Furstenhaupt T, Muellerleile PR, Kurjiaka DT, Kyle BD, Braun AP, Welsh DG.

Circ Res. 2014 Sep 12;115(7):650-61. doi: 10.1161/CIRCRESAHA.114.304056. Epub 2014 Aug 1.

Calcineurin/NFAT-Coupled TRPV4 Ca2+ Sparklets Stimulate Airway Smooth Muscle Cell Proliferation

Zhao, L., Sullivan, M.N., Chase, M., Gonzales, A.L., Earley, S

Am J Respir Cell Mol Biol. 2014 Jun;50(6):1064-75. doi: 10.1165/rcmb.2013-0416OC.

Regulation of Cerebral Artery Smooth Muscle Membrane Potential by Ca2+-activated Cation Channels.

Gonzales, A.L., and Earley, S.

Microcirculation. 2013 May;20(4):337-47. doi: 10.1111/micc.12023. Review.

Endogenous Cytosolic Ca2+ Buffering is Necessary for TRPM4 Activity in Cerebral Artery Smooth Muscle Cells

Gonzales, A.L., and Earley, S.

Cell Calcium. 2012 Jan;51(1):82-93. doi: 10.1016/j.ceca.2011.11.004. Epub 2011 Dec 7.

Basal protein kinase Cδ activity is required for membrane localization and activity of TRPM4 channels in cerebral artery smooth muscle cells.

Garcia Z.I., Bruhl A, Gonzales A.L., Earley S.

Channels (Austin). 2011 May-Jun;5(3):210-4. Epub 2011 May 1.

Pharmacological Inhibition of TRPM4 Hyperpolarizes Vascular Smooth Muscle.

Gonzales, A.L., Garcia, Z.I., Amberg, G.C., Earley, S.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C1195-202. doi: 10.1152/ajpcell.00269.2010. Epub 2010 Sep 8.

Vasoconstriction Resulting From Dynamic Membrane Trafficking of TRPM4 in Vascular Smooth Muscle Cells.

Crnich, R., Amberg, G., Leo, M.D., Gonzales, A.L., Tamkun, M.M Jaggar, J.H., Earley, S.

Am J Physiol Cell Physiol. 2010 Sep;299(3):C682-94. doi: 10.1152/ajpcell.00101.2010. Epub 2010 Jul 7.

Ca2+ Release from the Sarcoplasmic Reticulum is Required for Sustained TRPM4 Activity in Cerebral Artery Smooth Muscle Cells.

Gonzales, A.L., Amberg, G.C., Earley, S.

Am J Physiol Cell Physiol. 2010 Aug;299(2):C279-88. doi: 10.1152/ajpcell.00550.2009. Epub 2010 Apr 28.

A Dietary Agonist of TRPV3 Elicits Endothelium-Dependent Vasodilation.

Earley, S., Gonzales, A.L., Garcia, Z.I.

Mol Pharmacol. 2010 Apr;77(4):612-20. doi: 10.1124/mol.109.060715. Epub 2010 Jan 19.

Reduction in TRPC4 expression specifically attenuates G-protein coupled receptor-stimulated increases in intracellular calcium in human myometrial cells.

Ulloa, A., Gonzales, A.L., Zhong, M., Kim, Y., Cantlon, J., Clay, C., Ku, C., Earley, S., Sanborn., B.M.

Cell Calcium. 2009 Jul;46(1):73-84. doi: 10.1016/j.ceca.2009.05.003. Epub 2009 Jun 11.

Endothelium-Dependent Cerebral Artery Dilation Mediated by TRPA1 and Ca2+-Activated K+ Channels.

Earley, S., Gonzales, A.L., Crnich, R.

Circ Res. 2009 Apr 24;104(8):987-94. doi: 10.1161/CIRCRESAHA.108.189530. Epub 2009 Mar 19.

Turnover rate of the γ-aminobutyric acid transporter GAT1.

Gonzales, A.L., Lee, W., Spencer, S.R., Oropeza, R.A., Chapman, J.V., Ku, J.Y., Eskandari, S.

J Membr Biol. 2007 Dec;220(1-3):33-51. Epub 2007 Nov 9.